Effect of Gallic Acid on Distant Organ Stomach in Intestinal Ischemia Reperfusion Injury

Aim: To examine the effects of gallic acid (GA) in stomach rats undergoing intestinal ischemia/reperfusion (IR) with Beclin -1 immunostaining.
 Material-Metod: 24 male Wistar albino were divided into control, IR and IR+GA groups. For protocol, 60 minutes ischemia reperfusion applied. The small intestines control group removed by laparotomy abdomen was closed without applying anything else. Ischemia applied to superior mesenteric artery (SMA) for a clamp group. blood flow stopped on SMA minutes. 50 mg/kg given intraperitoneally animals, performed, closed. tissues placed paraffin blocks after routine histological follow-ups. Five micrometer-thick sections taken from stained Hematoxylin-eosin Beclin-1 Results: In group, degeneration gastric folds, apoptosis epithelial cells lamina muscularis observed. + GA folds improved, but cell infiltration propria muscular layer expression positively observed surface glands it that positive negative submucosa, while intensely expressed epithelium glands.
 Conclusion: By increasing beclin-1, treatment induced autophagy mucosal cells, triggered destruction damaged provided restoration layer.
 Keywords: Beclin-1, acid,